Process of obtaining curative animal serum.



Unrrnn sirnrns PATENT oFFIoE.

RiUHARD HEINRIOli DEUTSClziMANN, OF HAMBURG, GERMANY.

PROCESS OF OBTAINING GURATIVE ANIMAL SERUM.

Specification of Letters Patent.

Patented Dec. 8, 1908.

Application filed May 9, 1907. Serial No. 372,800.

' animals were infected with t e disease-axe the particular infectiousdisease, against citers in daily increasing doses, until the animalswere rendered immune against the same, whereupon the serum was separatedfrom the blood of the animals. With my improved process, however, eachanimal is infected but once with a dose of the germ of which .the serumis to be used. This dose must be just sufficient to afflict the animalwith the disease. As to the exact quantities of the disease-exciterswith which the animals are to be infected, no general rules can begiven, as the (loses vary" with the age,

weight and general constitution of the animal, but such doses may bereadily ascertained by persons skilled inserum-therapcutics. After theanimal has thus been once properly infected, yeast is added to its foodin daily increasing doses, until the animal has com letelyrecovcred,according to the method cscribed in my co-pcnding application filedAugust 14; 1906, Serial No. 330,589. Also for the exact doses of yeastno general data can be given, as-they vary with the peculiar germs andgeneral constitution of the animals. To ascertain the individual dosesisa matter very familiar to persons skilled in the science.

The serum prepared in the manner described constitutes a curativeagainst that peculiar disease, with the was infected.

Exam is: A serum against tuberculosis is prepare in the followingmanner:-Horses are infected with a dose of tubercle bacilli, consistingof several rods of a tubercle bacilli culture swelled in a physiologicalsolution of sodium 'ehlorid. yeast with their fodder, in quantities ofabout ally increased up to, 900 grams. As soon as the'horses have thusbeen cured of the artificially produced infection, they-are bled and theserum is extracted;

I-claim: f'

The horses are then given s5" After the ani- 'mal has recovered, it isbled and the serum is separated from the blood thus obtained.

germs of which the animal -300 grams daily, the dose being gradu-Process of obtaining curative animal serurn, which consists 111administering to an animal a single infectionof the germs of a diseaseagainst which the'seruln is to be used, adding increasing doses of yeastto the foodof the animal, bleeding the animal, and

separating the serum from the blood'thus v obtained, substantially asspecified.

Signed by me at Hamburg, Germany, this 27 day of April 1907.

1110mm) mmmcu DEUTSGHMANN.

Witnesses AUo sT .WENK, J. Borne.

